Placebo-Controlled, Double-Blind Clinical Trial.
Study conducted by: Shucun Qin(1), Weiqiang Zhang (1), Peng Qi (1), Meiling Zhao (1), Zhennan Dong (1), Yongchang Li (2), Xiaoman Zu (3), Zin Fang (2), Lei Fu (1), Jia-Shi Zhu (4) and Joseph Chang (4).
This double-blind, placebo-controlled clinical trial evaluated the ability of a natural product, a Monascus purpureus (Red Yeast) rice preparation, to regulate blood lipids in elderly patients with primary hyperlipidemia.
Seventy patients were randomly assigned to two groups: a M. purpureus rice preparation group and a placebo control group, 35 patients each group.
Sixty-five patients completed the trial, 34 in the M. purpureus rice group and 31 in the placebo group. After eight weeks, Monascus Purpureus rice preparation (1.2 g/day) significantly reduced serum total cholesterol by 25.9% and LDL-cholesterol by 32.8% (both p<0.001),>
Notably this M. Purpureus rice preparation, after 8 weeks lowered serum triacylglycerols by 19.9% (p=0.02), this was significantly (p=0.006) from the 2.3% increase observed in controls. When the overall effect of M. purpureus rice preparation was assesed relative to causing a change in the value of one or more lipid risk factors, 91.2 % of patients in the treatment group showed a significant improvement in their lipid profile.
Few side effects were observed during the 8-week treatment with M. Purpureus (Red Yeast) rice preparation. We concluded that use of M. purpureus rice preparation as a dietary supplement is safe in elderly and may represent an effective, novel modality to manage elevated serum cholesterol and triacylglycerols that influence cardiovascular health.
(1)
(2)
(3) The Clinic of Beijing Institute of Canbao Architectural Designing, Beijing, People's Republic of China
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