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TeGreen Homerun! Nutraingredients.com: "Mechanism For Green Tea's Anti-Cancer Action Revealed"

Pharmanex’ Tegreen97 has been at the forefront of many of the Green Tea discoveries. Now the research is catching on fire. On the company site, Pharmanex says, “Tegreen97 is an exclusive preparation of green tea leaf extract standardized to 97 percent polyphenols, the highest in the industry. Tegreen97 contains the same polyphenol content of approximately seven cups of traditionally brewed green tea.” Don’t miss the “key scientific study” reference at the bottom of this (in red), from the Px Product Info Page on Tegreen. (And remember that Tegreen ingredients are included in LifePak, although at less than $18.00 per bottle RETAIL, I’m beginning to think Tegreen by itself is grossly underpriced.)

For much more on Tegreen, see:

- Yet Another Study Extols the Benefits of Green Tea Catechins (Apr. 21, 2005)

- Study Finds Green Tea Polyphenols Support Protective Effects (Dec. 2, 2004)

- Study Finds Green Tea Supplements May Increase Liver Health (Sep. 7, 2004)

- Antioxidants in Green and Black Tea (WebMD Feb. 9, 2004)

- Green tea mechanism supports anti-cancer activity (Jan. 12, 2004)

- Green Tea Supplement May Delay Diabetes – “Rats' Fat Metabolism Improves with Tegreen Treatment” (WebMD Medical News, Apr. 16, 2003)

- Derivative Of Green Tea Leaf May Help With Metabolic Syndrome X, A Potentially Deadly Disorder (Science Daily, Apr. 9, 2003)

- Green Tea Extract Clinical Study at Stanford University (PDF file - “Stanford University physician presents results of effects of systemic nutrients on skin to The American Academy of Dermatology”) (March 22, 2003)

- Prostate Cancer Research Institute recommends Pharmanex product by name as definite prevention (Mar., 2002)

- Staying Healthy: 10 Foods That Pack A Wallop (Time Mag., Jan. 21, 2002)

- Tegreen Supporting Research

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The Tegreen ’97 Advantage

There are a lot of benefits that we can get from Tegreen aside from its antioxidant protection and thermogenic effect. Last April 8; Health Day News reported that a component of green tea helps kill cells of B-cell chronic lymphocytic leukemia (CLL), the second most common leukemia in American adults, according to new research.

Mayo Clinic researchers found that the component called epigallocatechin-3-gallate (EGCG) destroys leukemia cells by interrupting the communication signals they need to survive. The research appears online in the journal Blood.

CLL is most often diagnosed in people in their mid-to-late 60s. Chemotherapy is used to treat the most severe cases, but there is no cure for CLL.

In this study, the Mayo scientists found that EGCG prompted leukemia cells to die in eight of 10 patient samples tested in a laboratory.

"We're continuing to look for therapeutic agents that are nontoxic to the patient but kill cancer cells, and this finding with EGCG is an excellent start," study leader Dr. Neil E. Kay said in a prepared statement. "Understanding this mechanism and getting these positive early results gives us a lot to work with in terms of offering patients with this disease more effective, easily tolerated therapies earlier."

To view the entire article, click here .

Other than the said benefit, our Tegreen 97 contains 97 percent polyphenols which promote cellular protection. Daily supplementation with Tegreen ’97 may be considered as the first line of dietary support for health protection. Know more about Tegreen 97, click here . See also here Beauty of Innovation http://beautyofinnovation.multiply.com Contact +63.927.724.6878 to inquire

Additional info on nutrtion vs SARS

The fact of SARS (Severe Acute Respiratory Syndrome)

By Parco M. Siu, West Virginia University School of Medicine

The fact of the mysterious pneumonia has been widely spread in HK drives me to do a literature review on the suspected cause (i.e. coronavirus) of the SARS (Severe Acute Respiratory Syndrome). As a biomedical researcher, let me show you my concern and make the following suggestions.

The basic mechanism of viral attack is that the viruses replicate themselves using the host's (in this case is "our") DNA genetic replication system. By doing this, our body couldn't function well due to the massive viral replication. Supposing, the immune cells in our body will fight off the infected viruses quickly. However, the viruses are so smart that they could be able to produce some chemical substances to cause our immune cells to die. Besides, this coronavirus is a new kind of virus which belongs to a mutated strain and our body cannot recognize it.

No antibiotics have been proved to be 100% effective in treating viral infection so far. The only effective way to get rid of it is by ourselves. It likes a prolonged battle between the viruses and our immune response. In fact, viruses couldn't kill all the immune cells in a health individual. The stronger the immune function you have, the less the viral injury you get. Therefore, the degree of sickness after infection and the rate of recovery mainly depends on how strong your immune function is.

You cannot avoid the infection unless you avoid from those infected individuals/area. But, you can try your best to boost up your immune function by several regimes. Make sure you are "extremely healthy" at least during this critical period. Stronger immune function could keep the viral damage minimal even if you do get infected. Also, stronger immune function delays the onset of any detrimental effects from the viral infection. Scientists are now working on tracking the treatment and so make sure you are still surviving until an effective treatment occurs.

The following suggestions aim to strengthen your immune function within a short period of time.

1) Antioxidant nutraceuticals: Antioxidants are chemicals found in foods which exert a great value in strengthening our immune system. Boost up your immune function by taking a cocktail of antioxidant supplements.

- Vitamin E 1000 IU per day.

Alpha-tocopherol is the biological active form of vitamin E.

There are two forms of it: d-tocopherol and dl-tocopherol. d- is the natural form and dl- is the synthetic form. Try to get the d- form because it is absorbed faster in our body.

- Vitamin C (ascorbic acid) 1000 milligram (mg) daily.

Instead of taking supplement, you can take 2 pieces of citrus fruits (e.g. orange) a day to get the vitamin C.

- Beta-carotene, not more than 10000 IU daily

- Selenium, 200 microgram daily

- Zinc, not more than 500 milligram (mg) daily

- Lipoic acid, 50 mg daily

- Glutathione, 50 mg daily

No adverse effects have been reported from the above suggested supplementation dose.

Let green tea to be your daily beverage because it contains tremendous amount of antioxidant flavonoid, catechins.

Eat more tomatoes, broccoli or fruits and vegetables in red and dark green color. They carry a huge amount of antioxidant carotenoids, lycopene and carotene.

2) No intense physical activities during this critical period!

It has been shown that intense exercise will suppress your immune function (related to the upper respiratory infection) even several days following your workout. Instead of intense exercise, light-to-moderate workout helps if you have been training regularly.

3) Make sure you get enough carbohydrate foods (e.g. rice, food concentrated in starch... etc) because carbohydrate is the primary food for immune cells. Do some Gatorade or Pocari if needed since they are both good sources of carbohydrate.

4) Make sure you get enough sleep and don't make yourself so stressful! Anxiety, depression, and tired will influence your body's stress hormones (e.g. catecholamine and glucocorticoids) and so suppress your immune status.

5) Mouth-mask helps despite it is not 100% effective. But it can still decrease the chance from infection.

Green Tea Supplement May Delay Diabetes

Rats' Fat Metabolism Improves with Tegreen Treatment

By Daniel DeNoon WebMD Medical News Archive

Reviewed By Brunilda Nazario, MD on Wednesday, April 16, 2003

April 16, 2003 -- An herbal supplement made from green tea leaves might help fight diabetes.

The finding comes from researchers at supplement manufacturer Pharmanex. Hong Zu and colleagues overfed rats until their metabolism started to go haywire. When this happens to obese humans it's called metabolic syndrome X or insulin resistance..

A major feature of metabolic syndrome X is that the body starts losing control of blood sugar levels. In an effort to help, the pancreas makes more insulin. But the body becomes more and more resistant to insulin. Eventually, the whole system breaks down and diabetes, high blood pressure, and high cholesterol result.

Can green tea help? Pharmanex makes a green tea supplement called Tegreen. Zu's team gave the fat rats daily doses of Tegreen for eight weeks. Compared with rats that got no treatment, the Tegreen-taking rats lost abdominal fat. More importantly, they had lower levels of sugar, fat, and insulin in their blood.

"Oral administration of Tegreen is capable of improving glucose and lipid metabolisms induced by a high-calorie diet in an obese rat model," Zu and colleagues note in a news release. "This study clearly shows that Tegreen intervention can significantly decrease visceral fat depot and increase insulin sensitivity, presumably touching one of the pathological root causes of the potentially deadly syndrome."

Zu colleague Jia-Shi Zhu reported the findings at this week's meeting of the American Physiological Society.

---

SOURCES: Proceedings of the American Physiological Society. News release, American Physiological Society.

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Tegreen on Blood Sugar from AHA

Study on Pharmanex Tegreen 97(R) Finds Benefits in Blood Sugar Control and Weight Loss
Thursday June 2, 8:00 am ET

Pharmanex Scientists Invited to Present Landmark Study at Recent American Heart Association Meeting

PROVO, Utah, June 2 /PRNewswire-FirstCall/ -- Pharmanex, a Nu Skin Enterprises (NYSE: NUS - News) company, announced today a study that found Tegreen 97® to provide blood sugar control, body fat burning properties and weight-loss benefits in an experimental setting of Metabolic Syndrome X subjects -- a precursor to type-2 diabetes. The findings of the new study were recently presented at the American Heart Association's Sixth Annual Conference in Washington, D.C.

"We are honored by the American Heart Association's invitation to present our newest findings on Tegreen 97," said Joe Chang, Ph.D., president of Pharmanex. "The results of this study are very meaningful in building a greater body of knowledge related to two significant health issues today: weight gain and lack of blood sugar control. We have shown with this and other studies that Tegreen 97 can have a significant beneficial effect in managing these two health conditions."

Tegreen 97® is a proprietary, decaffeinated green tea extract standardized to 97 percent polyphenols -- two-thirds of which are catechins, the element responsible for the observed effect. Each capsule of Tegreen 97® contains the same amount of catechins as seven cups of the traditionally brewed green tea drink.

About the Study

The purpose of this study was to examine the effects of Tegreen 97® in enhancing insulin sensitivity and improving glucose-lipid metabolism. In addition, the research examined the effects of the proprietary green tea supplement in lowering body weight and weight of abdominal fat and inhibiting angiogenesis, which is the formation and differentiation of blood vessels, a key pathological process in the development of abnormal cells. Angiogenesis is hypothesized to play an important role in development of obesity. Following are the results of the study:

     *  Tegreen 97® enhanced insulin sensitivity*

     *  Improved glucose-lipid metabolism*

     *  Increased fat burning and decreased body fat percentage*

     *  Lowered body weight associated with inhibited angiogenesis.*

"Our findings proved that in addition to its significance in protecting cells from abnormal mutation, inhibition of angiogenesis by Tegreen 97 is associated with reduction of body weight," said Josh Zhu, senior director of clinical R&D for Pharmanex and chief researcher of the study. "Tegreen 97 not only supports the general belief in the anti-aging benefits of tea catechins but may also provide benefits to people with Metabolic Syndrome X, overweight and those with subsequent cardiovascular and brain health concerns."

Tegreen 97® is also included in LifePak®, the company's comprehensive multivitamin/mineral and antioxidant supplement.

Pharmanex

Pharmanex, a Nu Skin Enterprises company, applies pharmaceutical processes and scientific measurement to create nutritional supplements for more than 40 markets worldwide. Pharmanex® products are sold direct to the consumer through the Internet and a network of independent distributors. For more information, go to www.pharmanex.com.

The Company

Nu Skin Enterprises, Inc. is a global direct selling company operating in 40 markets throughout Asia, the Americas and Europe. The company markets premium quality personal care products under the Nu Skin® brand, science-based nutritional supplements under the Pharmanex® brand, and technology based products and services under the Big Planet® brand. Nu Skin Enterprises is traded on the New York Stock Exchange under the symbol "NUS."

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Antioxidants from Green Tea

These products have been independently evaluated by a team of scientists

Green Tea as an Antioxidant

Virtually everybody reading this page will have heard the term "antioxidant" by now (probably more times than you care to count). As a very broad generalization, the term "antioxidant" refers to the activity possessed by numerous vitamins, minerals and other phytochemicals to serve as protection against the damaging effects of highly reactive molecules known as free radicals. Free radicals have the ability to chemically react with, and damage, many structures in the body. Particularly susceptible to oxidative damage are the cell membranes of virtually all cells and the very source of our genetic material - DNA. Free radical reactions and oxidative damage have been linked to many of the diseases of aging such as heart disease and cancer.

The free radical theory of aging (and disease promotion) holds that through a gradual accumulation of microscopic damage to our cell membranes, DNA, tissue structures and enzyme systems, we begin to lose function and are predisposed to disease. Literally thousands of scientific studies have clearly documented the beneficial effects of dozens of antioxidant nutrients. There is certainly no shortage of nutrients and phytochemicals that possess significant antioxidant activity in the test tube - in fact, it seems as if every nutraceutical on the market possesses some degree of antioxidant activity. It is very well established that an increased dietary intake of antioxidant phytonutrients is linked to a reduced rate of oxidative damage as well as reduced incidence of chronic diseases such as heart disease and cancer. Perhaps the best specific data regarding antioxidant activity and the potential for real health benefits exists for green tea extract.

Aside form being the second-most consumed beverage in the world (water is the first), green tea has been used medicinally for centuries in India and China. The active constituents in green tea are a family of polyphenols (catechins) and flavonols which possess potent antioxidant activity. Large polyphenol molecules called tannins form the bulk of the active compounds in green tea, with catechins comprising nearly 90%. Several catechins are present in significant quantities; epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). EGCG makes up about 10-50% of the total catechin content and appears to be the most powerful of the catechins - with antioxidant activity about 25-100 times more potent than vitamins C and E. A cup of green tea may provide 10-40mg of polyphenols and has antioxidant activity greater than a serving of broccoli, spinach, carrots or strawberries. A number of commercial green tea extracts are standardized to total polyphenol content and/or EGCG content (but many are not).

Several epidemiological studies show an association between consumption of total flavonoids in the diet and the risk for cancer and heart disease. Men with the highest consumption of flavonoids (from fruits and vegetables) have approximately half the risk of heart disease and cancer compared with those with the lowest intake. The primary catechin in green tea, EGCG, appears to inhibit the growth of cancer cells as well as play a role in stimulating apoptosis (programmed cell death), both of which are crucial aspects for cancer prevention. In terms of heart disease protection, the potent antioxidant properties of polyphenols would be expected to reduce free radical damage to cells and prevent the oxidation of LDL cholesterol - both of which would be expected to inhibit the formation of atherosclerotic plaques.

This review concerns the specific actions of green tea extract as a powerful antioxidant (versus its use as a weight loss agent which has also been reviewed here). In this regard, green tea may be used by consumers looking for a broad-spectrum antioxidant or as specific treatment/prevention for certain cancers. For either of these uses, as a general antioxidant or as an "anti-cancer" agent, SupplementWatch urges you to look for the highest polyphenol content with the lowest caffeine content at the best price. Aside from the clear benefits of green tea as an antioxidant, however, recent studies have suggested a role catechins in promoting weight loss - and another review (using a different set of criteria) evaluates the value of specific green tea extracts as adjuncts to a weight loss regimen.

References
1. Benzie IF, Szeto YT, Strain JJ, Tomlinson B. Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer. 1999;34(1):83-7.
2. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5.
3. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8.
4. Gupta S, Ahmad N, Mohan RR, Husain MM, Mukhtar H. Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. Cancer Res. 1999 May 1;59(9):2115-20.
5. Hasegawa R, Chujo T, Sai-Kato K, Umemura T, Tanimura A, Kurokawa Y. Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane. Food Chem Toxicol. 1995 Nov;33(11):961-70.
6. Hirose M, Hoshiya T, Akagi K, Futakuchi M, Ito N. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Lett. 1994 Aug 15;83(1-2):149-56.
7. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology. 2000 Mar;141(3):980-7.
8. Lin JK, Liang YC, Lin-Shiau SY. Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol. 1999 Sep 15;58(6):911-5.
9. Sato D. Inhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea. Int J Urol. 1999 Feb;6(2):93-9.
10. Tanaka H, Hirose M, Kawabe M, Sano M, Takesada Y, Hagiwara A, Shirai T. Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats. Cancer Lett. 1997 Jun 3;116(1):47-52.
11. Wang ZY, Huang MT, Ho CT, Chang R, Ma W, Ferraro T, Reuhl KR, Yang CS, Conney AH. Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Res. 1992 Dec 1;52(23):6657-65.
12. Weisburger JH, Rivenson A, Aliaga C, Reinhardt J, Kelloff GJ, Boone CW, Steele VE, Balentine DA, Pittman B, Zang E. Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer. Proc Soc Exp Biol Med. 1998 Jan;217(1):104-8.
13. Xu Y, Ho CT, Amin SG, Han C, Chung FL. Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. Cancer Res. 1992 Jul 15;52(14):3875-9.
14. Zhu M, Gong Y, Ge G. Effects of green tea on growth inhibition and immune regulation of Lewis lung cancer in mice. Chung Hua Yu Fang I Hsueh Tsa Chih. 1997 Nov;31(6):325-9.

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